Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women.

John H. Morrison,1 Roberta D. Brinton,2 Peter J. Schmidt,3 and Andrea C. Gore4 1Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, 2Neuroscience Program, Departments of Biomedical Engineering and of Molecular Pharmacology and Toxicology of the School of Pharmacy, University of Southern California, Los Angeles, California 90033, 3Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1276, and 4The University of Texas at Austin, Division of Pharmacology–Toxicology, College of Pharmacy, the Institute for Neuroscience, and the Institute for Cellular and Molecular Biology, Austin, Texas 78712